Tamoxifen - is a synthetic, non-steroidal anti-estrogen compound. It works by concurrently binding to estrogen receptors inside cancer cells. It inhibits the synthesis and release of growth factors, and also stimulates the formation of progesterone receptors. This mechanism leads to inhibition of tumor cell division by a large number of estrogen receptors. 
Under the influence of tamoxifen, an increase in the concentration of a specific sex hormone that binds globulin is also observed, which leads to a decrease in the concentration of free estradiol in plasma. The result is an increase in the secretion of FSH by the anterior pituitary gland, which stimulates the ovaries to produce estrogen in the premenopausal period. 
It is believed that it induce the release of the transforming agent TGF-β, further enhancing the antitumor effect of the drug. About 34% of women with advanced breast cancer respond to treatment.


●    Treatment of breast cancer in premenopausal women and after it.

●    Tamoxifen is the drug of choice in patients undergoing radical surgery after the age of 60 who have lymph node metastases. 

●    It can be an alternative to ovarian irradiation. 

●    To reduce the risk of breast cancer.

●    After surgery and radiation therapy or for high-risk groups. 

●    It is also used in the induction of ovulation, mastalgia and mastopathy.

Tamoxifen is well absorbed from the gastrointestinal tract. The maximum concentration of the drug in the blood occurs after 4-7 hours after administration. Its main metabolite, N-demethylamoxifen, exhibits similar activity. Tamoxifen is metabolized in the liver, and 65% of the drug is excreted in the form of metabolites in the feces.

Buy tamoxifen 

For users who want to buy tamoxifen, need to know: what is this drug, what effect it has on the body and possible side effects. 
Tamoxifen is a steroid compound with an anti-estrogenic effect. In medicine, it is commonly used to treat breast cancer. This minimizes the possibility of binding estrogen in target tissues, competing with endogenous estrogens for a place with a cellular receptor. 
In bodybuilding, it is one of the most popular compounds that block estrogens. This is done to prevent flavoring, that is, to convert excess androgens into estrogens. The absence of this can lead, in particular, to: 

●    oily skin;
●    gynecomastia;
●    hormonal disorders. 

However, newbies who want to buy tamoxifen should be careful. And before using the drug, read its leaflet, which contains instructions, contraindications, data on adverse reactions and dosage and information on the use of the drug, or consult your doctor or pharmacist.
On the market there are several types that you can buy tamoxifen online.

●    Nolvadex-D (coated tablets).
●    Tamoxifen Sandoz (coated tablets).
●    Tamoxifen-Ebewe 20 (tablets).
●    Tamoxifen-EGIS (tablets).

Buy tamoxifen online is easy, it is available in the online pharmacy without a prescription or in steroid stores. But it is important to know about the drug interactions. 
1.    Tamoxifen enhances the effect of coumarin oral antimagulants. 
2.    The concomitant use of other hormonal drugs reduces the effect of tamoxifen. 
3.    The use of tamoxifen with cytotoxic drugs increases the risk of thromboembolic complications. 
4.    The concomitant use of mitomycin C increases the risk of thrombocytopenia, anemia and renal failure. 
5.    In combination with bromocriptine, its active metabolites increase.

Of the pharmacokinetic data on tamoxifen, the most important is the time of maximum serum concentration, which is 4 to 7 hours after administration and a half-life 7 days - only for tamoxifen and about 14 days for its metabolites, which have a strong anti-estrogenic effect.

Tamoxifen dosage

Tamoxifen dosage is very individual. Depending on the: 
●    type of steroid used;
●    doses of steroids;
●    body weight; 
●    sensitivity to excess testosterone. 

Naturally, high doses of SAA, as well as the use of highly androgenic steroids, will require higher doses of tamoxifen. On average, 20–40 mg a day, the drug is used on days when we “feel” such a need (expert version) and prophylactically on days when we take the highest doses of SAA or on the day of injection and the next day. 
Тamoxifen dosage  Prophylactically, tamoxifen can be used daily on the days of the steroid cycle, but this is not safe due to the large number of side effects. 
The PCT system recommended by many bodybuilders looks like this: from 4 to 6 weeks (depending on the healing ability of each user).
The first two weeks:

●    HCG, dosed at 1000 µV / E2D;
●    Aromasin is dosed at a concentration of 25 mg / day;
●    Nolvadex is dosed at 40 mg / day.
Weeks 2-6:
●    Nolvadex is dosed at 20 mg / day.

Over the past few decades, there are various PCT plans. The newbie is very confused about this, because different opinions are prevalent in the online communities of anabolic steroids. The most effective post-cycle treatment protocol will be supported by reliable scientific sources.

Tamoxifen side effects

Hypersensitivity to any component of the drug. The risk ratio for patients with a history of thromboembolism should be considered. It is necessary to exercise caution in people with leukopenia, thrombocytopenia, periodic blood monitoring.

Тamoxifen side effects 
They are relatively rare. Reducing the dose of the drug most often allows you to continue treatment. The most common side effects are vasomotor symptoms associated with estrogen deficiency: 
●    rash, 
●    nausea, 
●    vomiting, 
●    dizziness and headaches, 
●    irregular menstruation, 
●    hemorrhage in the genital tract, 
●    vaginal discharge, 
●    intensity of pain in the area of neoplastic changes and bone pain. 

Less common: thrombocytopenia, leukopenia, thromboembolic complications, vulvar itching, hypercalcemia, edema, elevated liver enzymes, irregular menstruation, or complete absence of menstruation (in women with menopause). Sometimes: partial hair loss. Corneal, cataract and retinopathy and uterine fibroids changes have been reported. The use of tamoxifen is associated with an increase in the number of uterine tumors. Reported cases of overdose in humans. In the case of an overdose, there is no specific antidote, therefore symptomatic treatment should be initiated. 
Pregnancy and lactation
Category D. Do not use during pregnancy. During treatment, women of childbearing age should use other methods than hormonal contraception. There is no information about whether the drug is excreted in human milk, during treatment with tamoxifen should stop breastfeeding.

Tamoxifen for men

In sports, it is used as probably the most popular antiestrogen, that is, an agent that blocks the activity of estrogen in the body. It is practically used only in men, because they have to be afraid of flavoring or turning excess androgens into estrogens. This, in turn, leads to male feminization effects, such as: 

●    gynecomastia, that is, the growth of adipose tissue around the breast; 
●    fat content, especially around the thighs, buttocks and abdominal cavity;
●    violate the hormonal balance.

It is for this reason that tamoxifen for men is used for sports purposes. 
One of the many myths that still revolve around gyms is that it weakens the action of anabolic steroids, mainly testosterone. In clinical trials conducted in a group of volunteers who received both testosterone (400 mg / week) and cyto-tamoxifen (20 mg / day), the effectiveness of testosterone and its metabolites ranged from 3.4% to minus 3.6%. Thus, the test showed that tamoxifen has a positive effect on potency and a slight negative effect.
Tamoxifen for men, a substance used under various factory names as an effective drug that has an unexpected, beneficial effect on the heart of men. Human studies have shown that, under the influence of Tamoxifen, blood circulation in the coronary vessels is improving. 

Since tamoxifen causes ovulation, it is recommended to use effective contraceptives. In the case of bone metastases, serum calcium levels should be controlled if lipid disorders coexist — triglyceride and cholesterol levels. 

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